■Short Review Article

Safety and efficacy of human adipose-derived mesenchymal stem cell conditioned media

Mohammad Ghazizadeh

WAARM Journal, 2018; 1: 21–24

Key words： Adipose-derived mesenchymal cells, conditioned medium, safety, efficacy

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Abstract

In recent years, mesenchymal stem cell therapy has attracted much attention due to their capability of homing into the site of injury and differentiating into multiple tissue types. However, it has been revealed that stem cells do not survive for a long time after administration, and that the advantages of mesenchymal stem cell therapy could be due to their secretome namely biologically active substances that they produce, which play a significant role in the regulation of key cellular processes. Therefore, conditioned media from the mesenchymal stem cell cultures which contain such materials may present a highly effective and desirable option for use in regenerative medicine therapies. Many studies in animal models and a few in humans have shown safety and efficacy of its application. So far, no serious adverse effects has been reported. The advantages of conditioned media include easy manufacturing, storage, handling, and longer shelf life. In addition, it provides a ready-to-use biological material. However, in order to establish the safety and efficacy of such material, strict regulatory measures for manufacturing and quality control, and standardization protocol will be mandatory.